The federal government started shutting down early Wednesday after Congress failed to approve a funding bill before the beginning of the new fiscal year — resulting in widespread ramifications for hundreds of programs and giving the Trump administration an avenue to fire federal workers en masse.

The U.S. Senate failed to advance two short-term government funding bills Tuesday when Democrats and Republicans deadlocked for the second time this month, with just hours to go before a shutdown that appeared nearly certain to begin at midnight.

The Trump administration is set to oversee the largest mass resignation in US history on Tuesday, with more than 100,000 federal workers set to formally quit as part of the latest wave of its deferred resignation program.

Impacts expected to be far greater than previous shutdowns since Trump administration plans to fire workers, rather than furlough them.

The Trump administration’s aggressive drive to carry out mass deportations of people without legal status already has led to U.S. citizens being swept up in raids and detained, according to news reports from around the country as well as immigration experts. Such detainments now will increase, experts predict.

The White House has sent guidance to departments and agencies, telling them that if a shutdown begins Wednesday, they’re expected to institute mass firings and layoffs.

President Donald Trump announced Monday that his administration believes it’s found one contributing factor of autism and a possible treatment, though experts have said such claims are inconclusive and not backed by scientific evidence.

Trump scales back Biden-era program aimed to close digital divide; cuts eligible Alaskans by 12%.

The Trump administration is ending the federal government's annual report on hunger in America, stating that it had become “overly politicized” and “rife with inaccuracies.”

State has turned over public data, but not private information such as driver’s license and partial Social Security numbers.

The moves represent an extraordinary state rebellion against the public health authority of the federal government.

The nonpartisan Government Accountability Office released a report Monday concluding the Federal Emergency Management Agency violated the law “when it withheld or delayed the obligation of” funding Congress approved for the Emergency Food and Shelter Program and the Shelter and Services Program.